Ethylation and methylation of hemoglobin in smokers and non-smokers

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Ethylation and methylation of hemoglobin in smokers and non-smokers.

Two previous studies demonstrated elevated levels of 3-ethyladenine in smokers' urine, suggesting that cigarette smoke may contain a DNA ethylating agent. We hypothesized that such an agent would also lead to elevated levels of N-terminal N-ethylvaline in hemoglobin. N-terminal N-alkylated valines in hemoglobin can be measured using a modified Edman degradation, which employs pentafluorophenyl ...

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Background: The cigarette compounds are associated with the increase in the incidence of oral cancer andprecancerous lesions. Salivary antioxidant system plays an important role in anti-carcinogenic capacity ofsaliva. Cotinine, a nicotine metabolite, has a longer half-life in comparison with nicotine and is a suitablemarker for exposure to cigarette smoke. This study aims to measure total antio...

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Determination of Total Antioxidant Capacity in Saliva of Smokers and Non-smokers with Chronic Periodontitis

Background: Periodontal diseases in smokers are 2.6 to 6 times higher than non-smokers and their response to treatment is much lower. Reducing levels of antioxidants and consequently increasing oxidative damage in the pathogenesis of periodontitis is effective. Regarding the importance of free radicals in the pathogenesis of periodontal diseases, the aim of this study was to investigate the eff...

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Background & Aims: Pressure ulcer is a serious problem in patients admitted to the intensive care unit. It is associated with major complications such as prolonged length of stay and delayed recovery. The aim of this study was to compare the incidence and grade of pressure ulcers in smokers and non-smokers admitted to the intensive care unit. Materials & Methods: This study is an analytical cr...

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ژورنال

عنوان ژورنال: Carcinogenesis

سال: 2002

ISSN: 1460-2180

DOI: 10.1093/carcin/23.11.1903